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How Genetics Influences Medicine Metabolism

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Patient responses to medicines vary widely and the reasons for this are diverse and complex. It is estimated that genetic factors account for 20 to 95% of patient variability in response to individual drugs.

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Patient responses to medicines vary widely and the reasons for this are diverse and complex. It is estimated that genetic factors account for 20 to 95% of patient variability in response to individual drugs. Genetic influences on drug metabolism interact with other factors such as age, gender, race/ethnicity, disease states, concomitant medicines and social factors, determining the outcome from treatment with any pharmacological agent. There is some confusion as to which term to use - 'pharmacogenetics' or 'pharmacogenomics?'

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Meet the educator

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Louis Roller
Honorary Associate Professor
Adjunct Associate Professor Louis Roller has been an academic at the Faculty of Pharmacy and Pharmaceutical Sciences Monash University for 57 years. He was on the Pharmacy Board of Victoria for 22 years and has significantly contributed to many editions of various pharmaceutical compendia, including the Therapeutic Guidelines, particularly the Antibiotic Guidelines. He is the author of hundreds of scientific and professional articles and has a passion for evidence-based knowledge. He lectures to pharmacists, medical practitioners, nurses, podiatrists,dentists and optometrists on a variety of therapeutic topics, particularly antibiotics, as well as giving many talks to the University of the Third Age on various medication-related issues. As at the end of December, 2020, he had delivered 54 talks to U3A Stonnington and an equivalent number to other U3A groups. With Dr Jenny Gowan, over the last 25 years, he has written articles on disease state management in the Australian Journal of Pharmacy. In 2012, he was made a life member of the Australasian Pharmaceutical Sciences Association and, in 2014, he was awarded the life-long achievement award of the Pharmaceutical Society of Australia.
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