Preventing Vitamin K Deficiency Bleeding in the Newborn
Published: 07 February 2024
Published: 07 February 2024
Vitamin K is an important component in the clotting cascade. Without it, newborn infants are at greater risk of haemorrhagic disease, with potentially fatal consequences. This is why all newborn babies are offered prophylactic Vitamin K in the immediate period after birth as a routine therapeutic intervention (Gold Coast Health 2023).
Vitamin K deficiency bleeding (VKDB), previously known as haemorrhagic disease of the newborn (HDNB), was first identified over a century ago. It describes bleeding in the newborn that is not due to traumatic birth or haemophilia. Caused by vitamin K deficiency due to insufficient prenatal storage of vitamin K, combined with insufficient vitamin K in breast milk, HDNB presents as unexpected bleeding, often with gastrointestinal haemorrhage, ecchymosis and intracranial haemorrhage (Ng & Loewy 2018; Nimavat 2019).
All newborn babies have inadequate reserves of Vitamin K at birth. This is partly because Vitamin K1 does not cross the placenta easily, resulting in low fetal plasma concentrations, and partly because vitamin K is found in relatively low concentrations in breast milk, making breastfed babies particularly vulnerable to VKDB (Gold Coast Health 2023; Eden et al. 2023).
There are three types of VKDB that have been identified, each classified according to when symptoms first appear:
(Gold Coast Health 2023; Nimavat 2019; Eden et al. 2023)
As Ng and Loewy (2018) report, vitamin K prophylaxis has been well-researched and shown to effectively reduce vitamin K deficiency bleeding of any severity in the first week of life.
A single intramuscular injection of vitamin K at birth can effectively prevent VKDB and is recommended for all newborn infants (Gold Coast Health 2023).
If oral prophylaxis is used, it should be administered in three doses:
(Gold Coast Health 2023)
Note that oral prophylaxis is less effective than a vitamin K injection. Other disadvantages of oral administration include the baby spitting out the dose of vitamin K or vomiting within the first hour of administration (Eden et al. 2023).
In Australia, it’s recommended that:
(NHMRC et al. 2010)
This final dose is not required in babies who are predominantly formula-fed, as milk formulas naturally contain vitamin K supplementation. It’s also important that the third dose is given no later than four weeks after birth, as the effect of earlier doses is known to decrease after this time (NHMRC et al. 2010).
For preterm babies, the situation is slightly different as they are at even greater risk of vitamin K deficiency bleeding due to hepatic immaturity and delayed gut colonisation with microflora (Ng & Loewy 2018).
Preterm infants may require a smaller dose of vitamin K (Pregnancy Birth & Baby 2022). They should only receive vitamin K via injection. Oral prophylaxis is not suitable for preterm infants as they are more likely to have feeding difficulties, and a smaller dose may be difficult to measure by mouth (NHMRC 2012).
Mihatsch et al. (2016) note that parents who receive prenatal education about the importance of vitamin K prophylaxis are far more likely to comply with administration after birth. The nurses and midwives who administer vitamin K also have a key role to play in educating and reassuring parents (Holley et al. 2020).
That said, according to Hamrick et al. (2016), the most common source of information for parents is the internet, with over 70% of parents saying they are influenced by online information. Common concerns frequently mentioned by parents include fears about:
Loyal et al. (2019) has explored the reasons behind parental reluctance to allow vitamin K administration and discovered the following four major themes:
Therefore, it’s recommended that:
(NHMRC et al. 2010)