REPLACE: Seven Steps to Remember During A Massive Blood Transfusion

12m of CPD
The amount of blood that a person receives during a massive blood transfusion can cause a set of complications that needs to be addressed concurrently. To remember the principles involved with managing a patient requiring a massive blood transfusion, remember the acronym REPLACE.

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What is this article about?

There are numerous considerations that need to be taken during a massive blood transfusion in order to prevent adverse outcomes for the patient. Good communication and maintaining safe transfusion practices and patient blood management principles are essential.


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  • 3 Assessment Questions

Further Learning

  • References

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Meet the educators

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Joanne Reading
ICU Clinical Educator
Joanne Reading is a clinical educator at the Royal Melbourne Hospital ICU. She holds a critical care graduate certificate and a Master of Health Science, with a focus on education. Joanne is passionate about ensuring that education is entertaining as it fosters critical thinking, and runs her own nursing education website at ‘Blogging for your Noggin’.
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Ausmed’s editorial team is committed to providing high-quality, well-researched and reputable education to our users, free of any commercial bias or conflict of interest. All education produced by Ausmed is developed in consultation with healthcare professionals and undergoes a rigorous review process to ensure the relevancy of all healthcare information and updates to changes in practice. If you have identified an issue with the education offered by Ausmed or wish to submit feedback to Ausmed's editorial team, please email with your concerns.
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What do others think?

246 reviews by Ausmed Learners
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Pamela Boyd
13 Oct 2021
Well done, explained well and gives a greater understanding so will assist practice, thank you.
Allison Chafer
08 Sep 2022
Registered Nurse
A very good read and information provided.
Beverley Hewitt
08 Nov 2022
Great resource.
Annabelle Bosnjak
04 Feb 2023
Registered Midwife
Great resource!
Jennifer English
14 Apr 2023
Registered Nurse
27 Sep 2022
Concise valuable review and resource
Lili Davidson
30 Apr 2023
Allison Chafer
02 Nov 2022
Registered Nurse
I repeated this resource because it is a high risk area and I want to educate others.
Portrait of Shreya Neupane
Shreya Neupane
07 Apr 2023
Registered Nurse
Sachiko Siellet
31 Jan 2023
Registered Nurse
excellent resource
4.6 / 5
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